Faithful replication of the genome is essential for development, tissue homeostasis and prevention of malignancy. Key steps in eukaryotic DNA replication include the licensing of replication origins, ...

The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...

Your DNA is constantly changing. And if it weren’t for genetic mutations, evolution wouldn’t exist. So, what would life be ...

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular aging, cancer, ...

Every time a cell copies its DNA, parts of the genome are exposed and vulnerable to damage or errors. Molecular biologist Simon Boulton is interested in how cells spot and repair damage to their DNA, ...

Researchers at the University of Minnesota Medical School have developed a new method called PARTAGE that provides a clearer picture of how the genome is regulated and disrupted in diseases like ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified. A protein that is involved in determining which enzymes cut or unwind DNA ...

As recently as the mid-20th century, aging was described by Nobel Prize laureate Peter Medawar as "an unsolved problem in biology." Today, scientists can analyze the activity of thousands of genes in ...

As genome editing therapies move through clinical trials to regulatory approval, scientists continue the quest for the holy ...