ajyoon commented Jun 23, 2022 Out of curiosity, if you have other python 3.x versions available on your system, are you able to install PyQt5 in them? Maybe the wheels aren't as available for 3.10 ...

Officially, Python 3.8 and above are not supported on Windows Vista SP2 and Windows Server 2008 SP2. Here, you can obtain unofficial Windows installers that bring back support for these older Windows ...