We've decided to retire and archive this project - there's just no safe way to run Python within pyodide safely with reasonable latency. Instead, we're working hard on Monty which should solve the ...

Raspberry Pi Pico's built-in bootloader allows you to write firmware via USB or SWD. However, in some situations, other interfaces may be useful. Picoboot3 now offers the options of UART, I2C and SPI.