Operation TrialBlazer coordinates FDA, NIH, and other HHS actions to reduce friction in US trial execution and counter China’s growing global share of registered and Phase I studies. An Expedited IND ...

The Food and Drug Administration (FDA) on Monday launched a new initiative to speed up early-stage clinical trials as part of an effort to reduce development timelines and reverse a growing trend of ...

Abstract: The Nelder-Mead simplex method is a well-known algorithm enabling the minimization of functions that are not available in closed-form and that need not be differentiable or convex.

Multi-Criteria Decision-Making (MCDM) encompasses a suite of mathematical and analytical tools designed to support complex decisions involving multiple, often conflicting criteria. At its core, MCDM ...

Abstract: This paper proposes a method to systematically assess the risk of mid-air collisions in Urban Air Mobility (UAM) operations, considering unique flight characteristics, mission requirements, ...