细胞极性核心蛋白PAR3通过液液相分离（LLPS）调控功能，而RASSF9作为其新相互作用伙伴，通过促进PAR3 LLPS维持细胞极性和抑制致癌信号。病理突变E58K、H60R破坏RASSF9-PAR3相互作用，削弱LLPS效应，提示该轴在肿瘤进展中起关键作用。 顶端-基底极性的建立对于上皮 ...

Fresh off a milestone month, the Oak Island Par 3 Golf Course hosted its first tournament on Aug. 3 in what has been a busy year for the local amenity. Monthly revenues exceeded $50,000 for the first ...

为探究慢性阻塞性肺疾病（COPD）肺气肿亚型的治疗方法，研究人员开展相关研究，发现 PAR3-PARD6B-PRKCI 复合物可调节 II 型肺泡上皮细胞（AEC2s）的增殖，为 COPD 治疗带来新突破。 慢性阻塞性肺疾病（Chronic Obstructive Pulmonary Disease，COPD）是一种让人头疼的进行性 ...

Have you ever wanted to enjoy a relaxed game of golf without the time commitment and competitiveness? Well now you can with the Par3 Golf Tour.

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Paclitaxel, belongs to tubulin-binding agents (TBAs), shows a great efficacy against breast cancer via stabilizing microtubules. Drug resistance limits its clinical application. Here we aimed to ...

Introduction: Mossy fiber sprouting (MFS) is a frequent histopathological finding in temporal lobe epilepsy (TLE) and is involved in the pathology of TLE. However, molecular signals underlying MFS ...

Planar cell polarity (PCP) signaling coordinates cell polarization along an axis orthogonal to its apical–basal axis and is essential for both tissue development and function. In inner ear sensory ...

The scaffold protein PAR3 and the kinase PAR1 are essential proteins that control cell polarity. Their precise opposite localisations define plasma membrane domains with specific functions. PAR3 and ...

尽管细胞极性在上皮性肿瘤发生中起重要作用，但极性蛋白丢失在前列腺肿瘤发生中的后果及其机制尚不清楚。利用条件敲除小鼠模型，我们在目前的研究中发现，极性蛋白Par3的缺失增加了前列腺上皮细胞的生长，提高了基底细胞中的对称细胞分裂，并使腔细胞 ...

Vertebrate neural tube formation depends on the coordinated orientation of cells in the tissue known as planar cell polarity (PCP). In the Xenopus neural plate, PCP is marked by the enrichment of the ...

Cell polarity is defined largely by the segregation of the cell cortex into domains populated by functionally distinct membrane proteins. Throughout the animal kingdom, these domains are formed by a ...