Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment has been the focus of a 30-year research question. New work from the Crick ...

Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

Adrian Woolfson, MD, PhD, says biology is becoming a general design and manufacturing platform poised to unlock a multi-trillion-dollar bioeconomy. Key to this transition will be the ability to write ...

Sidewinder represents the first DNA construction technology based on DNA 3-Way Junctions (3WJ), enabling the accurate construction of long, complex, and highly repetitive DNA sequences that have, ...

Replication stress (RS) is a major driver of genome instability in cancer. We discovered that the CHAMP1 complex, a set of proteins that assembles heterochromatin, plays a critical role in relieving ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...

This valuable paper describes the crystal structure of a complex of the Sld3-Cdc45-binding domain (CBD) with Cdc45, which is essential for the assembly of an active Cdc45-MCM-GINS (CMG) double-hexamer ...

Scientists have cracked the sweetpotato’s unusually complex DNA, uncovering its surprising ancestry and unlocking powerful tools to strengthen this essential global crop. Credit: Shutterstock Sweet ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...

Scientists at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) have made one of the most important discoveries to date in the study and treatment of BRCA1-deficient ...