Precision medicine exploits genetic differences to tailor drug treatments. Here the authors mapped ~1.17 M variants near drug-binding sites, built SNPdrug3D, and showed such variants often disrupt ...

Proteins, made of chains of amino acids, play critical roles in the body, whether building bone and muscle or supporting the immune system. While many proteins have a consistent folding pattern that ...

Homologous recombination (HR) is a universal DNA repair mechanism that faithfully restores genomic integrity following double-strand breaks (DSBs) in DNA. The details concerning the transfer of ...