PSC-UC has distinct colonic mucosa topography but shares a common mast cell state with UC during active disease.

True three-dimensional (3D) spatial biology provides a more physiologically relevant view of tissue biology and cellular interactions than conventional single-cell or two-dimensional (2D) thin-tissue ...

Illumina has filled two key C-suite posts, naming Mike Sullivan as chief commercial officer and Julie Coletti as chief legal officer, as the DNA sequencing giant works to keep its turnaround on track ...

The presence of tertiary lymphoid structures (TLSs)—ectopic lymphoid tissues that develop within tumors—has recently emerged as a critical biomarker for predicting favorable responses to cancer ...

A new study generated one of the most comprehensive spatially resolved transcriptomic maps of cellular communication between ...

Open access publishing makes scientific research more accessible to researchers, students, and the general public. Discover ...

The heart is a structurally complex organ where function is intimately tied to the precise spatial organization of diverse cell types. While single-cell RNA sequencing (scRNA-seq) has revolutionized ...

A novel spatial transcriptomics atlas developed by Northwestern Medicine scientists may improve the understanding of niche cellular interactions in the gastrointestinal tract that promote the ...

Spatial EcoTyper is a versatile framework for identifying spatially distinct multicellular communities, termed spatial ecotypes, from single-cell spatial transcriptomics data. In addition, it provides ...

This study addresses a critical challenge in spatial multi-omics: the effective integration of heterogeneous molecular modalities within complex tissue environments. By introducing SpaDDM, a ...

Lymph nodes are key sites of adaptive immune responses, yet how immune cells coordinate their activities in space and time remains poorly understood. We combined high-resolution spatial ...

Foster City, Calif. | January 27, 2026 — Signios Bio today announced the launch of a new grant program supporting innovative spatial transcriptomics research using the 10x Genomics Xenium 5K Spatial ...