OmicsBox 4.0 adds cloud integration, advanced transcriptomics tools like gene co-expression, and AI-powered summaries ...

A novel spatial transcriptomics atlas developed by Northwestern Medicine scientists may improve the understanding of niche cellular interactions in the gastrointestinal tract that promote the ...

Abstract: Spatial transcriptomics has revolutionized the ability to investigate transcriptional patterns within tissue morphology. However, many ST clustering pipelines operate on a single preselected ...

The tumor microenvironment (TME) of invasive lobular carcinoma (ILC) remains largely unexplored despite its clinical relevance and distinct biology. Using spatial transcriptomics, we reveal insights ...

Background Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions of pancreatic cancer with highly variable malignant potential. Current understanding of their biology remains ...

Background Most patients with biliary tract cancer (BTC) do not derive durable clinical benefit (DCB) from immune checkpoint inhibitors (ICIs), underscoring the urgent need for predictive biomarkers.

Please Don't Scroll Past This Can you chip in? The Internet Archive partners with libraries, archives, and institutions across the globe to preserve cultural heritage that would otherwise be lost ...

Metastatic breast cancer (MBC) remains the primary cause of mortality in breast cancer patients, driven by tumor heterogeneity, cellular evolution, and therapy-resistant clones. Traditional bulk ...

Biological systems are inherently three-dimensional—tissues form intricate layers, networks, and architectures where cells interact in ways that extend far beyond a flat plane. To capture the true ...

Abstract: Spatial transcriptomics enables the study of gene expression within the spatial context of tissues, offering valuable insights into tissue organization and function. However, technical ...

Unlike animals, plants are sessile organisms that must adapt to localized and fluctuating environmental stimuli, including abiotic and biotic stresses. While animals use mobile immune cells to ...

The liver is remarkable for its ability to regenerate after injury, yet when this process fails, acute liver failure (ALF) carries devastating outcomes. Traditional research methods, reliant on bulk ...